I’ve been experimenting with a fun library of PowerPoint artwork and templates called Doodleslide. It comes in the form of a plug-in for PowerPoint or Word on Office 2003-2010 (PC only, not Mac). If you use Doodleslide artwork throughout a presentation, it will certainly break the mould. It could work just as well for PowerPoint-based e-learning if that’s what you do.
I know it won’t work for every situation, but it will for some, and that’s worth the $49.95. You’d have to be careful mixing it with other styles of artwork, of course, to avoid producing something completely mad, but I’m sure it’s possible. Worth a look.